A new peptide synthesis method with imidazolium-type ionic oligomers
A new method of peptide synthesis that combines the benefit of soluble and solid support synthesis was developed at McGill University.
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This technology is a new method for the synthesis of peptides based on ionic oligomers that combine the benefits of homogenous reactions of soluble-support and the ease of separation of solid support. With imidazolium-type ionic oligomers as the support molecule, the amino acids assemble in the homogeneous phase without the need for excess reagents and block coupling of peptides is efficient. This new approach is suitable for large scale synthesis of peptides, generates high yield, and has an easy method of separation for the purification of polypeptide, oligosaccharide, and oligonucleotide products.
- Simple isolation compared to soluble support synthesis
- Larger loading levels than polystyrene resin-based solid supports
- Capability for block coupling and characterization of growing chains